Pair Name	All-trans retinoic acid, Salinomycin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	LRP6	hsa4040
	Down-regulation	Expression	BIRC5	hsa332
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CASP7	hsa840
	Down-regulation	Expression	CDC25A	hsa993
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Phosphorylation	GSK3B	hsa2932
Result	S+RA induced differentiation by β-catenin-inhibition-mediated up-regulation of C/EBPs and PU.1 and suppression of c-Myc. S+RA triggered apoptosis through β-catenin-inhibition-regulated ΔΨm collapse and caspase-3/7 activation. Taken together, our findings may provide novel therapeutic strategies for AML patients by targeting the WNT/β-catenin pathway.